From helicobacter pylori to glucose metabolism: can DOB values serve as a predictive marker?
<i>H. pylori</i> infection is associated with higher fasting glucose and triglyceride levels, and the <sup>13</sup>C-UBT DOB value showed modest predictive ability for glycemic abnormalities-especially in adults under 40 (AUC = 0.721). DOB may serve as an adjunct risk-stratification marker in younger populations. However, the single-center, cross-sectional design and lack of lifestyle and mechanistic biomarker data limit causal inference. Prospective multicenter cohort studies with serial UBT, clinical (diet, medications, exercise, socioeconomic factors) and biomarker (cytokines, GLP-1) measurements are needed to validate these findings.
Authors
- Dan He (ORCID: https://orcid.org/0000-0002-3786-5791)
- Hui Duan (ORCID: https://orcid.org/0009-0002-2403-2288)
- Yunlong Shi (ORCID: https://orcid.org/0000-0003-1325-8062)
- Zhou Yu (ORCID: https://orcid.org/0000-0002-2358-0090)
- Zhigang Huang (ORCID: https://orcid.org/0000-0002-1862-0182)
- Jie Xu (ORCID: https://orcid.org/0000-0003-3848-092X)
- Zhenjie Wang (ORCID: https://orcid.org/0000-0003-4916-8632)
- Zhaoyi Chen
Institutions
- Xuzhou Medical College (CN)
- Huaian First People’s Hospital (CN)
- Beijing Xuanwu Traditional Chinese Medicine Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fmed.2025.1612456
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00