Identification of novel hub genes and pathways predictive of fibrosis progression in cancer-related lymphedema through integrated multi-omics
ASPN is identified as a key molecular biomarker of fibrosis in CRL. Its predominant expression in ADSCs and strong association with progressive tissue remodeling suggest that ASPN holds potential as both a diagnostic indicator and a therapeutic target for CRL-related fibrosis.
Authors
- Junzhe Chen (ORCID: https://orcid.org/0009-0005-7573-0707)
- Yan Zhou (ORCID: https://orcid.org/0000-0003-2661-4011)
- Yunpeng Chen
- Shune Xiao (ORCID: https://orcid.org/0000-0002-4782-6198)
- Yun Wang (ORCID: https://orcid.org/0000-0002-3230-7686)
- Liangliang Wang (ORCID: https://orcid.org/0000-0001-8340-5190)
- Yaping Deng (ORCID: https://orcid.org/0000-0002-7015-9282)
- Chengliang Deng (ORCID: https://orcid.org/0000-0002-6593-3245)
Institutions
- Zunyi Medical University (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1625972
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China