Astrocytes from lamina cribrosa are involved in the autoregulatory function of optic nerve head vessels in vitro
Under <i>in vitro</i> OGD/R conditions, LC astrocyte were activated through the mTOR pathway, leading to increased secretion of PGE<sub>2</sub>, which locally regulates the dilation of VSMCs. In conclusion, LC astrocytes may regulate local blood flow in the ONH.
Authors
- Wenjia Zhang (ORCID: https://orcid.org/0000-0001-8912-7742)
- Libo Xiao
- Tingting Wan (ORCID: https://orcid.org/0000-0002-7548-9571)
- Changhui Li (ORCID: https://orcid.org/0000-0002-6179-2684)
- Xiaoxiao Feng
- Kangwei Jiao (ORCID: https://orcid.org/0000-0003-3202-5993)
- Liwei Zhang (ORCID: https://orcid.org/0009-0002-9382-9696)
Institutions
- Yunnan University (CN)
- Yunnan Institute of Parasitic Diseases (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fmolb.2025.1636882
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Yunnan Province