PERK/eIF2α pathway affected the thyroid hormone synthetic in hypertensive disorders of pregnancy rats
This investigation suggests that HDP might modulate Tg expression within thyroid tissue, possibly mediated through the PERK/eIF2α signaling cascade. This perturbation may compromise thyroid hormone synthesis, thereby predisposing pregnant rats to subclinical hypothyroidism.
Authors
- Luran Wang
- Maomao Sun
- Jie Jiang (ORCID: https://orcid.org/0000-0002-4077-0056)
- Yanni Wang (ORCID: https://orcid.org/0000-0001-5937-2931)
- Yue He (ORCID: https://orcid.org/0000-0002-7242-2363)
- Cheng‐Hung Wu (ORCID: https://orcid.org/0000-0002-7312-2370)
- Yonghui Yu (ORCID: https://orcid.org/0000-0001-7699-7482)
Institutions
- Shandong Provincial Hospital (CN)
- Weifang Maternity and Child Care Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fendo.2025.1552065
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China