Disease burden and trends in gout for adolescents from 1990 to 2021, with projections to 2050 globally, in East Asia and China: results from the Global Burden of Disease study 2021

The escalating adolescent gout burden in East Asia and China reflects synergistic effects of obesity, metabolic syndrome, and lifestyle changes. Gender disparities highlight underrecognized risks in females. Sociodemographic transitions initially exacerbate then mitigate gout burden, emphasizing the need for early interventions targeting modifiable risks. Strengthening healthcare infrastructure and gender-specific prevention strategies are critical to curb projected increases in high-risk regions.