Selective vulnerability of stellate cells to gut dysbiosis: neuroanatomical changes in the medial entorhinal cortex
These findings suggest AIGD selectively alters mECII stellate cell morphology through peripheral immune signaling or microbial metabolites, independent of local microglial activation. This study highlights the role of gut microbiota in shaping neuronal architecture and supports microbiome-targeted strategies to counteract dysbiosis-associated neuroanatomical changes.
Authors
- Safa Shehab (ORCID: https://orcid.org/0000-0002-1628-8876)
- Mohammad I. K. Hamad (ORCID: https://orcid.org/0000-0002-7413-0305)
- Mohammed M. Nakhal
- Shaikha Al Houqani
- Shamsa BaniYas
- Ayishal B. Mydeen
- Reem Almazrouei
- Rasha Alkamali
- Mahra Alsulaimi
- Abdulrahman Alzaabi
- Omar Aleissaee
- Hamad Almansoori
- Marim Elkashlan
- Faheema Nafees
- Mohamed Alfahim
Institutions
- United Arab Emirates University (AE)
Publication Details
- Journal
- Frontiers in Neuroanatomy
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fnana.2025.1589287
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- United Arab Emirates University