Elevated NK and T cell-associated cytokines in plasma are associated with serological response to influenza vaccination
In conclusion, plasma chemokines and cytokine levels prior to or in the first few days post-influenza vaccination may be predictive of serological responses to vaccination, with changes in IFN-γ, IL-17A, and IL-15 post-vaccination possibly indicative of the activation of cell-mediated immunity. These findings support the need for larger, high-resolution studies exploring the role of plasma proteomics in serological responses to influenza vaccination.
Authors
- Harry Pickering (ORCID: https://orcid.org/0000-0003-2348-5410)
- Monica Cappelletti
- Ted M. Ross (ORCID: https://orcid.org/0000-0003-1947-7469)
- Elaine F. Reed (ORCID: https://orcid.org/0000-0002-3524-545X)
- Michael A. Carlock (ORCID: https://orcid.org/0000-0003-4077-7386)
- David W. Gjertson (ORCID: https://orcid.org/0000-0002-0749-1442)
Institutions
- Cleveland Clinic (US)
- University of California, Los Angeles (US)
- University of Georgia (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1662942
- Citations
- 1
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Institute of Allergy and Infectious Diseases