Investigating the Therapeutic Impact of Choline Salicylate Gel, Benzocaine, Lidocaine, Amlexanox, and Povidone-Iodine in the Treatment of Mouth Ulcers: A Comparative Study of Five Different Therapeutic Agents

Objective: The primary objective of this study was to compare the therapeutic efficacy of five commonly used topical agents Choline Salicylate Gel, Benzocaine Gel, Lidocaine Gel, Amlexanox Oral Paste, and Povidone-Iodine Solution in treating mouth ulcers. The study aimed to evaluate their effectiveness in pain relief, reduction of inflammation, ulcer healing time, and patient satisfaction, while also assessing their safety profiles. Materials & Methods: A total of 150 patients diagnosed with mouth ulcers were enrolled and randomized into five equal groups, with each group receiving one of the specified treatments. Each treatment was applied as per standard dosage guidelines for seven days. Pain intensity was measured using a visual analog scale (VAS) at baseline, Day 3, and Day 7. Ulcer size was assessed using calipers, and healing time was noted. Patient satisfaction scores and any adverse effects were also recorded. Data were analyzed using ANOVA and paired t-tests to determine statistical significance between treatment outcomes. Results: All treatments were effective in reducing pain and inflammation, though to varying extents. Choline Salicylate Gel provided rapid pain relief, while Amlexanox Oral Paste significantly accelerated healing and reduced ulcer size by Day 7. Lidocaine Gel was effective for short-term pain management but showed moderate results for inflammation and healing. Benzocaine Gel demonstrated efficient numbing effects but slower overall recovery. Povidone-Iodine Solution was effective in preventing secondary infections, although its healing efficacy lagged behind others. No severe adverse effects were reported across all treatment groups. Conclusion: Choline Salicylate Gel and Amlexanox Oral Paste proved to be the most effective treatments for mouth ulcers, combining rapid pain relief and enhanced healing outcomes. These findings suggest their potential as first-line therapies for managing oral ulcers. However, individual patient needs and tolerances should guide the choice of treatment