PD-1 Bispecific Killer Engager (PD-1 BiKE) effectively depletes effector T lymphocytes in experimental autoimmune encephalomyelitis
The IgG-like PD-1 BiKE bound to both cellular targets, CD16 and PD-1, and was able to deplete primary PD-1<sup>+</sup> T lymphocytes in the EAE model. Altogether, the work showcases the effectiveness of using BiKEs to deplete non-malignant cells.
Authors
- Shuyun Dong (ORCID: https://orcid.org/0000-0003-2988-6864)
- Mingnan Chen (ORCID: https://orcid.org/0000-0002-7080-9804)
- Brian D. Evavold (ORCID: https://orcid.org/0000-0002-3561-3494)
- Lauren Naatz (ORCID: https://orcid.org/0000-0001-7898-9371)
- Yujia Zhai (ORCID: https://orcid.org/0000-0003-4697-5797)
Institutions
- University of Utah (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1644903
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Multiple Sclerosis Society
- National Institutes of Health