The Retrospective Analysis of Patients with Primary Immune Thrombocytopenia: The Associated Factors with Bleeding and The Factors with Treatment Response

The Retrospective Analysis of Patients with Primary Immune Thrombocytopenia: The Associated Factors with Bleeding and The Factors with Treatment Response Aim: Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder characterized by isolated thrombocytopenia and is twice as common in women as in men.Although severe bleeding is rare, identifying risk factors for bleeding can guide treatment decisions.This study aimed to evaluate the relationships between age, platelet count, hemoglobin level, mean platelet volume (MPV), and bleeding in ITP patients.Additionally, the impact of variables such as age, gender, platelet count, bone marrow megakaryocyte count, MPV, intravenous immunoglobulin (IVIG) response (in splenectomized patients), and remission duration on treatment response was investigated.Methods: We retrospectively analyzed the medical records of 101 patients (81 females, 20 males) diagnosed with ITP and followed at the Hematology Outpatient Clinic of Karadeniz Technical University Farabi Hospital between 2008 and 2011.Statistical analysis was performed to assess the relationship between clinical/laboratory variables and bleeding, first-line treatment response, and splenectomy outcomes.Results: Low platelet count and elevated MPV were significantly associated with bleeding (p<0.05).MPV elevation was also a favorable factor in predicting first-line treatment response.Among splenectomized patients, a positive response to IVIG was associated with better splenectomy outcomes (p<0.05).Furthermore, longer remission durations were significantly correlated with favorable splenectomy responses (p<0.01).Conclusion: MPV may serve as a useful marker for both bleeding risk and treatment response in ITP.A favorable IVIG response may predict splenectomy success.The association between remission duration and splenectomy response adds valuable insight to individualized management strategies in ITP.