Targeting FCRLA to induce necrosis in lung adenocarcinoma: a novel strategy for prognosis and therapy via MPT-Driven pathways
<i>RASGRP2</i>, <i>CD79A</i>, and <i>FCRLA</i> have been identified as being associated with MPTDN in LUAD cells. <i>FCRLA</i> knockdown may suppress mitochondrial permeability transition through specific pathways, thereby driving LUAD cell necrosis and providing potential targets for subsequent LUAD treatment.
Authors
- Xiaowei Cao (ORCID: https://orcid.org/0000-0003-1845-9111)
- Zhigang Cai (ORCID: https://orcid.org/0000-0002-2190-4928)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-8581-4649)
- Xiaoli Sun (ORCID: https://orcid.org/0000-0002-0509-3109)
- Shusen Zhang (ORCID: https://orcid.org/0000-0001-8714-6683)
- Bowen Cai
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Xingtai People's Hospital (CN)
- First Hospital of Shijiazhuang (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
- Hebei Science and Technology Department (CN)
- Hebei Institute of Physical Education (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1596179
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00