Bidirectional modulation of somatostatin-expressing interneurons in the basolateral amygdala reduces neuropathic pain perception in mice
Our findings suggest that, in addition to PV<sup>+</sup> neurons, SST<sup>+</sup> interneurons in the BLA play complex roles in modulating neuropathic pain following nerve injury and may serve as a potential target for future neuromodulation interventions in chronic pain management.
Authors
- Cody Slater (ORCID: https://orcid.org/0000-0002-6388-8233)
- Qi Wang (ORCID: https://orcid.org/0000-0001-8656-1439)
- Brett E. Youngerman (ORCID: https://orcid.org/0000-0002-4792-3190)
- Marina Sorrentino
- Aditya Apte
- Julia Fernald
Institutions
- Columbia University Irving Medical Center (US)
- Columbia University (US)
Publication Details
- Journal
- Frontiers in Pain Research
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fpain.2025.1602036
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Science Foundation
- National Institutes of Health
- Division of Chemical, Bioengineering, Environmental, and Transport Systems