Development and evaluation of <i>N</i> -acetyl cysteine-grafted polyamidoamine dendrimers for enhanced brain delivery of donepezil hydrochloride
N -acetyl cysteine-conjugated PAMAM G4 dendrimers for brain-targeted delivery of donepezil. The developed system showed high loading, sustained release, improved cell viability, and enhanced pharmacokinetics for Alzheimer’s therapy.
Authors
- Keerti Jain (ORCID: https://orcid.org/0000-0002-4121-4596)
- Teeja Suthar (ORCID: https://orcid.org/0000-0001-5690-9043)
Institutions
- National Institute of Pharmaceutical Education and Research (IN)
Publication Details
- Journal
- RSC Pharmaceutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5pm00119f
- Citations
- 2
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Institute of Pharmaceutical Education and Research, Raebareli