Longitudinal Autoantibody and Proteomic Signatures of Disease Progression in Systemic Sclerosis
Dynamic changes in autoantibody titers, rather than baseline levels, were more strongly associated with SSc trajectory. Proteomic signatures suggest lipid metabolism and oxidative stress as potential drivers, highlighting novel biomarkers and therapeutic targets for personalized SSc management.
Authors
- Hui Luo (ORCID: https://orcid.org/0000-0001-5593-8563)
- Ying Long (ORCID: https://orcid.org/0000-0002-8657-6988)
- Quan‐Zhen Li (ORCID: https://orcid.org/0000-0002-7257-0489)
- Muyao Guo (ORCID: https://orcid.org/0000-0003-1347-0848)
- Sijia Liu (ORCID: https://orcid.org/0000-0001-9763-1164)
- Jing Huang (ORCID: https://orcid.org/0009-0002-7218-9845)
- Wei Yu (ORCID: https://orcid.org/0000-0002-3154-5084)
- Honglin Zhu (ORCID: https://orcid.org/0000-0001-8724-2835)
Institutions
- Central South University (CN)
- GeneCopoeia (United States) (US)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.1002/art.43354
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China