Standardized freeze-dried FMT: is the ideal protectant out there?

HM and T5 both proved effective for freeze-dried FMT, with HM yielding the highest recovery but not significantly outperforming T5. Given its simplicity and consistent results, T5 may serve as a reliable standalone protectant or as a base for improved formulations. IG5 showed significant bacterial loss and is unsuitable. Further biological validation and stability data will guide the development of optimized freeze-dried oral FMT capsules.

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Publication Details

Journal
Frontiers in Microbiology
Published
2025-08-13
DOI
https://doi.org/10.3389/fmicb.2025.1618067
Citations
2
Primary Topic
Intestinal and Peritoneal Adhesions
Type
article
Field-Weighted Citation Impact
4.01
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article

Standardized freeze-dried FMT: is the ideal protectant out there?

Samuel Bellais, Biba Nebbad, Muriel Paul, Alix Pourrat et al.
2 citations
Frontiers in Microbiology
Intestinal and Peritoneal Adhesions
4.01
article

Standardized freeze-dried FMT: is the ideal protectant out there?

Samuel Bellais, Biba Nebbad, Muriel Paul, Alix Pourrat, Vinciane Baillieu, Solene Ansel, Maxime Leonardi, Pierre Poiron
article en
2 citations

Abstract

HM and T5 both proved effective for freeze-dried FMT, with HM yielding the highest recovery but not significantly outperforming T5. Given its simplicity and consistent results, T5 may serve as a reliable standalone protectant or as a base for improved formulations. IG5 showed significant bacterial loss and is unsuitable. Further biological validation and stability data will guide the development of optimized freeze-dried oral FMT capsules.

Frontiers in MicrobiologyVol. 16
Hôpitaux Universitaires Henri-Mondor (FR), BIOASTER (FR)
Openalex Percentile: Top 6%
Intestinal and Peritoneal Adhesions
4.01
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