Standardized freeze-dried FMT: is the ideal protectant out there?
HM and T5 both proved effective for freeze-dried FMT, with HM yielding the highest recovery but not significantly outperforming T5. Given its simplicity and consistent results, T5 may serve as a reliable standalone protectant or as a base for improved formulations. IG5 showed significant bacterial loss and is unsuitable. Further biological validation and stability data will guide the development of optimized freeze-dried oral FMT capsules.
Authors
- Samuel Bellais
- Biba Nebbad
- Muriel Paul (ORCID: https://orcid.org/0000-0002-0004-0286)
- Alix Pourrat
- Vinciane Baillieu
- Solene Ansel
- Maxime Leonardi
- Pierre Poiron
Institutions
- Hôpitaux Universitaires Henri-Mondor (FR)
- BIOASTER (FR)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fmicb.2025.1618067
- Citations
- 2
- Primary Topic
- Intestinal and Peritoneal Adhesions
- Type
- article
- Field-Weighted Citation Impact
- 4.01