ACTN2, regulated by PRDM9, affects the growth and inflammation of vascular smooth muscle cells by interacting with PDLIM1 in intracranial aneurysms
This study reveals that PRDM9 regulates ACTN2 expression through epigenetic modifications and interacts with PDLIM1 to mediate VSMC function and aneurysm progression. The study provides a theoretical basis for clinical intervention.
Authors
- Guangxu Zhang (ORCID: https://orcid.org/0000-0003-1112-3244)
- Jinbing Zhao (ORCID: https://orcid.org/0000-0001-5059-1556)
- Hongyi Liu (ORCID: https://orcid.org/0000-0002-3914-252X)
- Zhiqiang Yu (ORCID: https://orcid.org/0000-0001-5725-3728)
Institutions
- Nanjing Brain Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fnmol.2025.1606973
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00