Analysis of imaging signatures in 18F-DOPA PET of glioblastoma treated with dose-escalated radiotherapy
Our study showcased the potential of employing quantitative features derived from <sup>18</sup>F-DOPA images to refine the stratification of patients with unmethylated MGMT for dose escalated therapy. Moreover, the change of these features can serve as valuable tools for monitoring treatment responses following radiotherapy.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- J. Qian (ORCID: https://orcid.org/0000-0001-5276-4158)
- Derek Richard Johnson (ORCID: https://orcid.org/0000-0002-4217-5517)
- Jann Nagina Sarkaria (ORCID: https://orcid.org/0000-0001-7489-4885)
- Joon H. Uhm (ORCID: https://orcid.org/0009-0003-1048-546X)
- Deanna Pafundi
- Sani H. Kizilbash (ORCID: https://orcid.org/0000-0001-8568-1519)
- Mark Jacobson
- Michael W. Ruff (ORCID: https://orcid.org/0000-0001-8513-9615)
- Bradley J. Kemp (ORCID: https://orcid.org/0000-0002-2360-2368)
- Mark J. Zakhary (ORCID: https://orcid.org/0000-0003-4333-648X)
- Debra H. Brinkmann (ORCID: https://orcid.org/0000-0002-0812-3094)
- Elizabeth Yan
- Timothy J. Kaufmann (ORCID: https://orcid.org/0000-0001-7483-1569)
- Paul D. Brown (ORCID: https://orcid.org/0000-0003-0022-4533)
- Nadia N. Laack (ORCID: https://orcid.org/0000-0002-4385-6349)
- Christopher H. Hunt (ORCID: https://orcid.org/0000-0003-0301-0493)
- William G. Breen (ORCID: https://orcid.org/0000-0001-8039-2398)
- Maasa H. Seaberg
- Hok Seum Wan Chan Tseung
- Yan Zhang (ORCID: https://orcid.org/0000-0003-0727-7697)
Institutions
- University of Maryland, Baltimore (US)
- Mayo Clinic (US)
- Jacksonville College (US)
- University of California San Francisco Medical Center (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fonc.2025.1623313
- Citations
- 1
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Institutes of Health
- National Cancer Institute