Localized and historical hypermobile spectrum disorders share self-reported symptoms and comorbidities with hEDS and HSD
We found that patients with L-HSD/H-HSD had many symptoms and comorbidities that closely resembled HSD suggesting that revised diagnostic criteria for hEDS and HSD should include L-HSD/H-HSD within a diagnosis of HSD. Additionally, our data further suggest that patients with HSD (including L-HSD/H-HSD) have more symptoms/comorbidities than patients with hEDS.
Authors
- Bala Munipalli (ORCID: https://orcid.org/0000-0002-1188-5495)
- Ashley A. Darakjian (ORCID: https://orcid.org/0009-0001-1913-9200)
- Katelyn A. Bruno (ORCID: https://orcid.org/0000-0001-8980-6059)
- Caroline Hamilton (ORCID: https://orcid.org/0000-0003-0546-9222)
- Chrisandra Shufelt (ORCID: https://orcid.org/0000-0001-6886-9210)
- Stacey M. Menton (ORCID: https://orcid.org/0000-0003-2283-1684)
- Emily R. Whelan (ORCID: https://orcid.org/0000-0002-0410-0549)
- Dacre R. T. Knight (ORCID: https://orcid.org/0000-0001-6206-0680)
- Paldeep S. Atwal (ORCID: https://orcid.org/0000-0002-8515-744X)
- Shilpa Gajarawala (ORCID: https://orcid.org/0000-0002-8891-6157)
- Elaine Murphy (ORCID: https://orcid.org/0000-0002-6302-9279)
- DeLisa Fairweather (ORCID: https://orcid.org/0000-0003-3093-1810)
- David O. Hodge (ORCID: https://orcid.org/0000-0001-5148-9174)
- Jessica M. Gehin (ORCID: https://orcid.org/0000-0003-4757-416X)
- Jessica J. Fliess (ORCID: https://orcid.org/0009-0004-7689-3172)
- Hanna Sledge
- F. F. Wilson (ORCID: https://orcid.org/0000-0002-5552-0842)
- Gabriel J. Weigel (ORCID: https://orcid.org/0009-0009-7410-923X)
- S. Christian Kocsis (ORCID: https://orcid.org/0009-0005-5778-6336)
- Cameron J. Hartmoyer (ORCID: https://orcid.org/0009-0003-4924-8197)
- Alayna M Puls
- Max W Strandes (ORCID: https://orcid.org/0009-0008-4793-1933)
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- WinnMed (US)
- University of Florida (US)
- Palm Beach Neurology (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fmed.2025.1594796
- Citations
- 3
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Mayo Clinic
- American Heart Association
- Ehlers-Danlos Society
- National Institutes of Health