Identification of hub genes and prediction of the ceRNA network in adult sepsis
This study identified four hub genes (CLEC4D, GPR84, S100A12, and HK3) with significant prognostic value in sepsis and predicted a ceRNA network (NEAT1-hsa-miR-495-3p-ELF1) regulating their expression. The integrated analysis reconfirmed the concurrent presence of hyperinflammation and immunosuppression in hospitalized sepsis patients. These findings enhance the understanding of sepsis pathogenesis and identify potential therapeutic targets.
Authors
- Kangyi Xue
- Haihua Luo (ORCID: https://orcid.org/0000-0003-4607-9917)
- Zhaoqian Zhong (ORCID: https://orcid.org/0000-0001-5930-4488)
- Kan Wu (ORCID: https://orcid.org/0009-0006-5231-6295)
- Li Chen (ORCID: https://orcid.org/0000-0002-9478-6432)
- Lei Li (ORCID: https://orcid.org/0000-0003-1281-6472)
- Hui Luo (ORCID: https://orcid.org/0000-0003-1522-5002)
- Fen Li (ORCID: https://orcid.org/0009-0003-5933-9949)
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Institute of Infection and Immunity (CA)
- Southern Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-08-13
- DOI
- https://doi.org/10.7717/peerj.19619
- Citations
- 3
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China