High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy
Our findings indicate that reduced placental SIRT3 expression is a key molecular feature in advanced maternal age. This reduction may be related to increased risk of maternal vascular malperfusion and adverse pregnancy outcomes, potentially through mechanisms involving exacerbated oxidative stress and impaired placental vascular function; however, further studies are needed to clarify these associations.
Authors
- Jie Wu (ORCID: https://orcid.org/0000-0002-7590-4368)
- You‐Lin Qiao (ORCID: https://orcid.org/0000-0001-6380-0871)
- Feifei Hu
- Yue Hu (ORCID: https://orcid.org/0000-0002-9814-0233)
- Xin Sun
- Huiru Wu (ORCID: https://orcid.org/0000-0002-8335-7712)
- Yao Chen (ORCID: https://orcid.org/0000-0002-2683-9256)
- Mingli Huang
- Su Yao (ORCID: https://orcid.org/0000-0001-9808-1184)
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-08-13
- DOI
- https://doi.org/10.3389/fgene.2025.1636834
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harbin Medical University
- Natural Science Foundation of Heilongjiang Province