APRF+ BIOMATERIALS IN DENTISTRY: MECHANISMS, CLINICAL APPLICATIONS AND PERSPECTIVES

APRF+ (Advanced Platelet-Rich Fibrin Plus) is an innovative biomaterial, derived from autologous blood, which plays an essential role in dental regenerative medicine. Through a specific centrifugation process, APRF+ obtains a three-dimensional matrix rich in fibrin, platelets and leukocytes, capable of gradually releasing essential growth factors, such as PDGF, TGF-β and VEGF. This controlled release stimulates angiogenesis, cell proliferation and osteogenesis, being useful in various clinical applications such as guided bone regeneration, sinus lifting, periodontal treatments and dental implant integration. Among its advantages are high biocompatibility, reduction of post-operative complications and the ability to accelerate the healing of soft and hard tissues. However, APRF+ also has limitations, such as the variability of outcomes depending on the patient's health and the limited duration of growth factor release. Future research focuses on integrating APRF+ with nanotechnology and other biomaterials to expand its efficacy and clinical applications. APRF+ represents an important step in dentistry, with the potential to turn regenerative treatments into a standard of practice.