Salvage of a Distal Ulnar Nonunion with Teriparatide Therapy

We present an 80-year-old woman with osteoporosis who sustained a fall, resulting in a closed left distal radius fracture and a grade I open ulna fracture. She underwent open reduction internal fixation. Four months later, the radius healed, but the ulna showed delayed union. Initial bone stimulator therapy was ineffective, and computed tomography scans confirmed nonunion at 6 and 9 months after surgery. Revision surgery was considered, but her treatment was changed to teriparatide, a parathyroid hormone analog that stimulates bone healing. Within 2 months, progressive ulnar healing was noted, avoiding revision surgery. At 15 months, x-rays confirmed full healing, and the patient resumed weight-bearing. This case underscores teriparatide as a promising nonsurgical option for fracture nonunion in osteoporotic patients, meriting further research.

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Publication Details

Journal
Journal of Hand Surgery Global Online
Published
2025-08-13
DOI
https://doi.org/10.1016/j.jhsg.2025.100785
Primary Topic
Orthopedic Surgery and Rehabilitation
Type
article
Field-Weighted Citation Impact
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article

Salvage of a Distal Ulnar Nonunion with Teriparatide Therapy

Shelley S. Noland, Erwin A. Kruger, Cynthia S. Payne, Bithika Thompson et al.
Journal of Hand Surgery Global Online
Orthopedic Surgery and Rehabilitation
article

Salvage of a Distal Ulnar Nonunion with Teriparatide Therapy

Shelley S. Noland, Erwin A. Kruger, Cynthia S. Payne, Bithika Thompson, Jeffrey D. Hassebrock, Krishna Unadkat
article en

Abstract

We present an 80-year-old woman with osteoporosis who sustained a fall, resulting in a closed left distal radius fracture and a grade I open ulna fracture. She underwent open reduction internal fixation. Four months later, the radius healed, but the ulna showed delayed union. Initial bone stimulator therapy was ineffective, and computed tomography scans confirmed nonunion at 6 and 9 months after surgery. Revision surgery was considered, but her treatment was changed to teriparatide, a parathyroid hormone analog that stimulates bone healing. Within 2 months, progressive ulnar healing was noted, avoiding revision surgery. At 15 months, x-rays confirmed full healing, and the patient resumed weight-bearing. This case underscores teriparatide as a promising nonsurgical option for fracture nonunion in osteoporotic patients, meriting further research.

Journal of Hand Surgery Global OnlineVol. 7(5)
Mayo Clinic in Arizona (US), Mayo Clinic Hospital (US)
Openalex Percentile: Top 66%
Orthopedic Surgery and Rehabilitation
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