Tanshinone IIA suppresses fibro-adipogenic progenitor differentiation and attenuates fat infiltration in rotator cuff injury via Wnt/β-catenin pathway
Tan IIA inhibits FAP adipogenesis through Wnt/β-catenin signaling activation, reducing fatty infiltration and enhancing shoulder function in RCT, suggesting Tan IIA as a potential treatment.
Authors
- Amila Kuati
- Qian Wang (ORCID: https://orcid.org/0000-0002-4171-9738)
- Xinghua Li (ORCID: https://orcid.org/0000-0003-2156-5775)
- Ruiyan Zhang (ORCID: https://orcid.org/0000-0002-6624-4660)
- Tihui Wang
- G.Q. Liu (ORCID: https://orcid.org/0009-0009-0053-6861)
- Yumei Zhang
- Wenhua Mao
Institutions
- Fujian Medical University (CN)
- Peking University (CN)
- Peking University Third Hospital (CN)
- Union Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-08-13
- DOI
- https://doi.org/10.1016/j.reth.2025.08.004
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00