A Single Institutional Experience Using Romiplostim to Treat Therapy‐Related Thrombocytopenia in Pediatric Solid Tumor Patients
Chemotherapy-induced thrombocytopenia (CIT) is a common toxicity in patients with cancer, leading to chemotherapy dose reductions and increased platelet transfusions. Although there are well-documented data using thrombopoietin receptor agonists (TPO-RA) in both adult CIT and pediatric immune thrombocytopenia, there is a paucity of data in pediatric CIT. This is a single institutional, retrospective study evaluating the use and safety of romiplostim in pediatric patients with solid tumors undergoing cancer treatment. Romiplostim was well tolerated and appeared to provide clinical benefit. This report advocates for further research using TPO-RA in pediatric patients being treated for cancer.
Authors
- Emily K. Slotkin (ORCID: https://orcid.org/0000-0002-4463-5759)
- Jodi V. Mones (ORCID: https://orcid.org/0000-0002-1327-775X)
- Audrey Mauguen (ORCID: https://orcid.org/0000-0003-3236-6093)
- Ira J. Dunkel (ORCID: https://orcid.org/0000-0001-8091-6067)
- Gerald A. Soff (ORCID: https://orcid.org/0000-0002-8781-903X)
- Michael Vincent Ortiz (ORCID: https://orcid.org/0000-0001-9379-314X)
- Melanie Degliuomini (ORCID: https://orcid.org/0000-0003-2078-4706)
- Michael Curry (ORCID: https://orcid.org/0000-0002-0261-4044)
- Shakeel I. Modak (ORCID: https://orcid.org/0000-0002-7280-1726)
- Katherine Armstrong
Institutions
- Hackensack University Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Miami Health System (US)
- Flatiron Health (United States) (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1002/pbc.31977
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children's Cancer Research Fund
- Conquer Cancer Foundation
- Amgen
- Rally Foundation
- American Society of Clinical Oncology
- Memorial Sloan-Kettering Cancer Center
- Swedish Orphan Biovitrum
- National Institutes of Health
- National Cancer Institute