PHYSICAL PROPERTIES AND BIOACTIVITIES OF CURCUMIN-LOADED IN-SITU IMPLANT

Curcumin, the important active component in turmeric extracts, has gained significant attention demonstrating notable effectiveness across a wide range of human pathological conditions. This study explores the development and characterization of borneol and ibuprofen-based in situ implant (ISI) systems loaded with curcumin, designed for advanced therapeutic applications. Curcumin ISI solution enabled self-transformation into matrix at 40% w/w concentration. Ibuprofen and borneol enhanced curcumin transformation at lower concentration. These ISI systems exhibited low viscosity and swift transformation aiding for their administration by injection. Macroscopic and cross-sectional imaging provided insights into their phase inversion process. Curcumin-loaded borneol-based ISI demonstrated high antioxidant activity. Both curcumin-loaded borneol-based and ibuprofen-based ISIs showed efficient antimicrobial activities against related periodontitis pathogens. These findings underscore the potential of curcumin-loaded borneol and ibuprofen-based ISI systems as promising candidates for localized drug delivery, particularly in treating periodontitis.