PULSED Nd:YAG LASER-SYNTHESIZED SILVER NANOPARTICLES WITH HIGH SENSITIVITY FOR GLUCOSE DETECTION

Diabetes Mellitus (DM) affects not only adults but also children, leading to an urgent need for the development of a reliable glucose sensors. This study introduces a simple method to develop a Localized Surface Plasmon Resonance (LSPR)-based glucose sensor utilizing silver nanoparticles (AgNPs). AgNPs were synthesized using pulsed Nd:YAG laser ablation in liquid at different laser-pulse diameters ranging from 1 mm to 5 mm. The wavelength, energy, and frequency of the Nd:YAG laser were fixed at 1064 nm, 200 mJ, and 4 Hz, respectively. The morphology of AgNPs was observed to be spherical, with an average diameter of 42.5 nm. Analysis of the UV-Vis results showed that the interaction of AgNPs with glucose at various concentrations (i.e., 0–10%), resulted in changes in the LSPR wavelength. The wavelength shifted to longer values as the glucose concentration increased. The AgNPs’ sensing sensitivity to detect glucose was 0.421 nm/%, with excellent linearity (0.98) and a detection range from 0% to 10%. These findings provide significant contributions to the development of reliable glucose sensors, with important application prospects in the management of diabetes mellitus.