Correlations Between Gut Microbiome Changes, Gut Barrier Function, and Immune Homeostasis in COVID-19 Patients: The Role of Gut Microbiota in Immunity and Cancer Prevention

Systemic inflammation and immunological dysregulation are linked to COVID-19 infection, and there is mounting evidence that gut barrier failure and gut microbiota dysbiosis are related. Gaining knowledge of these relationships could help explain how diseases develop. By measuring biomarkers and cytokine levels, this research aims to analyze the relationships among gut microbiota alterations, gut barrier function, and immunological homeostasis in COVID-19 patients. Using IBM SPSS (version 26) with Pearson Correlation, Chi-Square testing, independent t-tests, and Multivariate Regression analysis, a comparative study was conducted using gut barrier biomarkers (Zonulin, LPS, I-FABP) and cytokine levels (IL-6, IL-10, TNF-α). In COVID-19 individuals, there were notable variations in gut barrier biomarkers and cytokine levels, with robust associations suggesting a connection between immune dysregulation and gut barrier failure. Gut microbiota dysbiosis and gut barrier dysfunction are significantly associated with immune homeostasis disturbance in COVID-19 patients, which may be a contributing factor to the disease's severity and progression.