Ameliorative role of coenzyme Q10 against simvastatin induced myopathy of skeletal muscles in adult male albino rats.

Background: Simvastatin (SV) is one anti hyperlipidemic drugs. It acts by inhibition of HMG-CoA reductase. It can cause side effects, including muscle pain. Coenzyme Q10 (CoQ10) is present in the body as an antioxidant, as it is necessary for cell maintenance. Aim: This study was designated to evaluate the ability of CoQ10 to repair damaged skeletal muscle triggered by SV in albino rats. Material and Methods:40 adult male albino rats were used in this study, divided into 4 distinct groups; each was composed of 10 rats and received the drug diluted in distilled water via a gastric tube for a period of 12 weeks. Group I received a daily dosage of usual food and water. Group II administered SV at a dose of 10 mg/kg/day. Group III received SV at a dose of 10 mg/kg/day with CoQ10 at a dose of 10 mg/kg/day. Group IV received 10mg/kg/day of SV for 12 weeks, followed by 12weeks stopping of drug. At the end of experiment, muscle tissues of gastrocnemius were collected from groups and processed for H&E, PAS and toluidine blue. Biochemical analyses were conducted to assess levels of CK. Results: Administration of SV in group II leads to elevation in the CK with histological changes in muscle fiber in H&E, PAS and toluidine blue. On the other hand administration of CoQ10 in group III showed a significant decrease in CK, with improvement in architecture of the muscle fiber. Conclusion: CoQ10 administration improve the skeletal myopathy induced by SV.