C-reactive protein as a predictor of activation of immune-inflammatory processes in the early postoperative period in Crohn’s disease

The Objective was to study changes in serum C-reactive protein (CRP) concentration in the postoperative period in patients with Crohn’s disease (CD), as well as to substantiate and develop an algorithm for using predictors of inflammation to prevent the possible development of postoperative complications. Methods and materials. In 62 patients, who underwent surgical interventions performed for CD complications, CRP parameters was studied daily during the first seven days and on the twelfth day of the postoperative period. Results. In 27.4 % of cases in the postoperative period, CD patients showed activation of the immune-inflammatory process, which increased the risk of postoperative complications. The threshold values of CRP were determined, which can serve as predictors of the activation of immune-inflammatory processes in the early postoperative period in Crohn’s disease. Conclusion. A pathological increase in CRP on the 3–4th day after surgery should be considered as a predictor of activation of immune-inflammatory processes and as an indication for therapeutic correction.