Latent autoimmune diabetes in an adult male presenting with diabetic ketoacidosis precipitated by sepsis

Latent autoimmune diabetes in adults (LADA) is a relatively common form of diabetes, but it remains under-researched. It shares characteristics of both type 1 and type 2 diabetes mellitus (T1D and T2D). While autoimmunity is a recognised underlying cause of LADA, certain environmental factors such as obesity, lack of physical activity, and smoking may also contribute to its development. Due to its overlapping features with T2D, LADA is often misdiagnosed as type 2 diabetes and initially managed with oral hypoglycaemic agents, which can delay the timely initiation of insulin therapy. Although rare, there are reports of patients with LADA presenting for the first time with diabetic ketoacidosis (DKA). We describe here a case of an adult male with latent autoimmune diabetes and sepsis who presented with DKA at onset.

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Publication Details

Journal
International Journal of Research in Medical Science
Published
2025-01-01
DOI
https://doi.org/10.33545/26648733.2025.v7.i2b.136
Primary Topic
Diabetes and associated disorders
Type
article
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article

Latent autoimmune diabetes in an adult male presenting with diabetic ketoacidosis precipitated by sepsis

Isha Koul, Alpana Waghmare, Akash Parab, Abhishek Chande et al.
International Journal of Research in Medical Science
Diabetes and associated disorders
article

Latent autoimmune diabetes in an adult male presenting with diabetic ketoacidosis precipitated by sepsis

Isha Koul, Alpana Waghmare, Akash Parab, Abhishek Chande, Hemant Gupta
article en

Abstract

Latent autoimmune diabetes in adults (LADA) is a relatively common form of diabetes, but it remains under-researched. It shares characteristics of both type 1 and type 2 diabetes mellitus (T1D and T2D). While autoimmunity is a recognised underlying cause of LADA, certain environmental factors such as obesity, lack of physical activity, and smoking may also contribute to its development. Due to its overlapping features with T2D, LADA is often misdiagnosed as type 2 diabetes and initially managed with oral hypoglycaemic agents, which can delay the timely initiation of insulin therapy. Although rare, there are reports of patients with LADA presenting for the first time with diabetic ketoacidosis (DKA). We describe here a case of an adult male with latent autoimmune diabetes and sepsis who presented with DKA at onset.

International Journal of Research in Medical ScienceVol. 7(2)
Good health and well-being
Openalex Percentile: Top 77%
Diabetes and associated disorders
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