Spinal and Leptomeningeal Infantile Glioma With <i>Raf1</i> Fusion: Diagnostic Challenges for a Potentially Novel Tumour Type
We report an infantile spinal tumour with diffuse leptomeningeal dissemination and features of a glioma with CUX1::RAF1 fusion and the DNA-methylation class, infant-type hemispheric glioma. This strange case was similar to a previously reported tumour reported in the literature, which clustered perfectly with our case. Further reports are needed to confirm the hypothesis that this neoplasm represents a novel tumour type.
Authors
- Antoine Listrat
- Mathilde Duchesne (ORCID: https://orcid.org/0000-0002-5621-7335)
- Alice Métais (ORCID: https://orcid.org/0000-0002-5924-3555)
- Jill Serre
- Ke Qin
- Arnault Tauziède‐Espariat (ORCID: https://orcid.org/0000-0002-9979-0297)
- Cécilia Rousselot‐Denis
- Mathilde Filser (ORCID: https://orcid.org/0000-0002-5074-8100)
- Julien Masliah‐Planchon (ORCID: https://orcid.org/0000-0002-5596-3926)
- Pascale Varlet (ORCID: https://orcid.org/0000-0002-8164-1517)
- Kathleen M. Schieffer (ORCID: https://orcid.org/0000-0002-2688-8680)
- Lauren Hasty
- Julie Fuseau
- Euphrasie Servant
Institutions
- Université de Tours (FR)
- Nationwide Children's Hospital (US)
- Inserm (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Centre Hospitalier Sainte-Anne (FR)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- FHU Neurovasc (FR)
- Hôpital Dupuytren (FR)
- Institut Curie (FR)
Publication Details
- Journal
- Neuropathology and Applied Neurobiology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/nan.70032
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00