Predictive Value of Neutrophil-to-Lymphocyte Ratio in Patients with Acute Myocardial Infarction in Coronary Angiographic Profile and Left Ventricular Ejection Fraction in North Indian Population

A BSTRACT Background: Neutrophil-to-lymphocyte ratio (NLR) refers to the absolute ratio of peripheral blood neutrophils to lymphocytes, which can reflect the state of systematic inflammation, and coronary artery disease is closely related to systemic inflammation. We aimed to define the severity of inflammation by evaluating the correlation of NLR with coronary angiographic profile and left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (MI). Materials and Methods: This study was conducted on newly diagnosed acute MI patients who were admitted to our tertiary healthcare center. NLR was calculated as absolute values of neutrophil divided by absolute lymphocyte count from the venous blood collected at admission. Echocardiography and coronary angiography were done as per the routine standard of care protocol for these patients. The association of NLR with coronary angiographic profile and EF was evaluated, and P < 0.05 was considered statistically significant. Results: A total of 102 patients were included in the study. Males were more than females in the study population (78 vs. 24), and the mean age of the study population was 60.4 years. Non-ST elevation MI was the most prevalent MI in this cohort (35.3%), followed by anterior wall MI (29.4%) and inferior wall MI (7.8%). There was a negative correlation between NLR and EF, and Pearson’s correlation coefficient was 0.5136 ( P < 0.05). The mean NLR was 4.15, 5.03, and 4.97 in single vessel disease, double vessel disease, and vessel disease patients, respectively, which was statistically significant ( P < 0.001). Conclusion: NLR had a good ability in predicting prognosis in terms of coronary angiographic severity and change in LVEF in acute MI patients.