The Effect of <i>Ocimum tenuiflorum</i> Ethanolic Extract on Cholesterol Level of Diabetic Mice

Dyslipidemia are conditions that frequently occur with Diabetes Melitus. Several previous studies have reported suboptimal management of dyslipidemia. The effect of Ocimum tenuiflorum or holy basil as anti-dyslipidemia has not been widely reported. This study was conducted to evaluate the effect of Ocimum tenuiflorum extract on the colesterol leve lof diabetic mice. In this study, we prepared 18 diabetes mice and divided into 3 groups based on the treatment, as follow: treatment 1 (56 mg/kgBW of Ocimum tenuiflorum extract), treatment 2 (112 mg/kgBW of Ocimum tenuiflorum extract), and control. Cholesterol level was measured after 2 weeks of treatment. The lowest colesterol level after treatment was in Group 2 (112 mg/kgBW), followed by Group 1 (56 mg/kgBW), and the last, or the highest colesterol level was had by control group. The difference in mean of colesterol level after treatment between groups was found to be significant based on the One Way Anova and Post hoc Tamhane tests with a P value &lt;0.05. These findings can support the potential of Ocimum tenuiflorum as a new pharmacotherapeutic agent for the management of diabetes-induced dyslipidemia. Additional research is needed to to evaluate this potency in humans.