Composite indices of inflammation, immunity, and nutrition. Calculation formulas, interpretation, and clinical significance (literature review)

Introduction . New aggregated hemacytometric indices of the ratio of neutrophils, lymphocytes, platelets, monocytes, Creactive protein, albumin can be promising markers of the objective state and dynamics of critical conditions in cardiology, oncology, infectious pathology and intensive care. The objective was to compare methods for calculating new composite hemacytometric indices and discussion of the conditions of their use and effectiveness in intensive care. Materials and methods. A literature search was conducted using PubMed, Medline, and Google Scholar databases in the period 2020–2024. The search includes publications indexed in Scopus. Results . Combined indicators characterizing the status of inflammation, immunity, nutrition during intensive care are more accurate in comparison with traditional single hematological and biochemical parameters. However, the diagnostic value of these indicators is still variable, and little has been studied in intensive care. Conclusion . It is obvious that the use of hemacytometric, combined (composite) indices in various fields of clinical medicine is an objectively new step in the interpretation of laboratory parameters.