Iridium-catalyzed asymmetric reductive amination of C2-acylpyridines
Chiral 1-pyridin-2-yl-ethylamines are significant building blocks for synthetic chemistry and pharmaceutical sciences, while their stereoselective and practical synthesis remains challenging and usually troublesome. Herein, we present a novel iridium-catalyzed direct asymmetric reductive amination of 2-acylpyridines with anilines, affording a series of chiral 1-pyridin-2-yl-ethylamines with up to 97% yield and 95% ee. A 5 mmol scale reaction is also performed to demonstrate the practicality of this method.
Authors
- Zhiwen Nie (ORCID: https://orcid.org/0000-0002-8204-9099)
- Hengzhi You (ORCID: https://orcid.org/0000-0001-8904-5050)
- Qin Yin (ORCID: https://orcid.org/0000-0003-3534-3786)
- Gang Wang (ORCID: https://orcid.org/0000-0002-0641-8593)
Institutions
- Shenzhen Institute of Information Technology (CN)
- Shenzhen University (CN)
- Chinese Academy of Sciences (CN)
- Harbin Institute of Technology (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Shenzhen Technology University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04017e
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Shenzhen University
- Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
- Shenzhen Science and Technology Innovation Program
- Division of Materials Research