Whole blood BDNF is lower in patients with depression and unchanged by escitalopram in patients and healthy controls
wb-BDNF reflects the total blood BDNF pool and avoids platelet aggregation-related confounds seen in s-BDNF measures. wb-BDNF could be used as diagnosis but not as a prognosis biomarker, in MDD. Further research is needed to investigate changes in BDNF reservoirs and their implications.
Authors
- Gitte M. Knudsen (ORCID: https://orcid.org/0000-0003-1508-6866)
- Brice Ozenne (ORCID: https://orcid.org/0000-0001-9694-2956)
- Sanjay S. Aripaka (ORCID: https://orcid.org/0000-0003-3499-5547)
- Martin Balslev Jørgensen (ORCID: https://orcid.org/0000-0002-1321-8901)
- Vibe G. Frøkjær (ORCID: https://orcid.org/0000-0002-9321-2365)
- Alberte Wollesen Breum (ORCID: https://orcid.org/0000-0002-8399-4308)
- Arafat Nasser (ORCID: https://orcid.org/0000-0002-0305-3883)
- Sophia Armand (ORCID: https://orcid.org/0000-0001-6368-3329)
- Miriam L. Navarro
Institutions
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.pnpbp.2025.111470
- Citations
- 1
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Wellcome Trust
- Innovationsfonden
- Lundbeckfonden
- Grosserer L. F. Foghts Fond
- H. Lundbeck A/S