Refining antibiotic cocktail regimens for pseudo-germ-free mice and their impact on gut microbiome and pancreatic tumor proteomics
Refined antibiotic regimens effectively generate PGF mice with minimized side effects, enabling reproducible studies of microbiota-host interactions. Microbiota depletion alters the tumor proteomic landscape and improves chemotherapy response in PDAC, highlighting the therapeutic potential of microbiome manipulation in cancer treatment.
Authors
- Suraphan Panyod (ORCID: https://orcid.org/0000-0001-8998-375X)
- Yi‐Chia Lee (ORCID: https://orcid.org/0000-0002-8160-1216)
- Chih-Ta Chen (ORCID: https://orcid.org/0000-0003-0660-7340)
- Yi-Ling Lo
- Chin‐Hsien Lin (ORCID: https://orcid.org/0000-0001-8566-7573)
- Yu-Tang Yang
- Ming‐Shiang Wu (ORCID: https://orcid.org/0000-0002-1940-6428)
- Cheng‐Chih Hsu (ORCID: https://orcid.org/0000-0002-2892-5326)
- Lu‐Ping Chow (ORCID: https://orcid.org/0000-0002-4420-211X)
- Wei‐Ting Liao (ORCID: https://orcid.org/0000-0003-4281-1082)
- I‐Hsuan Lo
- Wei‐Kai Wu (ORCID: https://orcid.org/0000-0002-9476-8998)
- Yen-Peng Lee (ORCID: https://orcid.org/0000-0003-2368-7215)
- Yi‐Hsun Chen (ORCID: https://orcid.org/0000-0001-9981-5143)
- Hsiao-Li Chuang (ORCID: https://orcid.org/0000-0002-3718-9076)
- Tzung‐Yi Lin (ORCID: https://orcid.org/0000-0002-1995-6673)
- Po‐Cheng Kuo
- C. Yen
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- National Institutes of Applied Research (TW)
- National Taipei University (TW)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.015
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00