Ramulus Mori (Sangzhi) alkaloids enhance pancreatic β-Cell maturation and function by targeting the CD81/endoplasmic reticulum stress pathway
SZ-A promotes β-cell maturation and function by suppressing CD81-mediated ER stress. These findings reveal a novel therapeutic mechanism of SZ-A and identify CD81 as a potential target for T2DM intervention.
Authors
- Yuchen Zhao (ORCID: https://orcid.org/0009-0007-1097-9063)
- Shuiya Sun
- Xihua Lin (ORCID: https://orcid.org/0000-0002-8537-4479)
- Shuainan Liu (ORCID: https://orcid.org/0000-0002-6740-1605)
- Sunyue He (ORCID: https://orcid.org/0000-0002-4475-212X)
- Lusi Lu (ORCID: https://orcid.org/0000-0001-7631-1102)
- Lei Lei (ORCID: https://orcid.org/0000-0002-1614-846X)
- Wenjing Zhang (ORCID: https://orcid.org/0000-0002-0617-5886)
- Yi-ming Liu (ORCID: https://orcid.org/0000-0001-7906-2244)
- Chunyi Xu (ORCID: https://orcid.org/0009-0001-1032-2287)
- Jiaqiang Zhou (ORCID: https://orcid.org/0000-0002-5698-6417)
- Nan Wu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sir Run Run Shaw Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1016/j.phymed.2025.157150
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Natural Science Foundation of Zhejiang Province