The Impact of Physicochemical Descriptors on the Biological Activity of 5-Fluorouracil Analogs
5-FU remains a key anticancer drug, especially for colon, breast, and other cancers. This study developed a QSAR model to predict the anticancer activity of seven 5-FU analogs. Physicochemical properties, calculated using ChemSW and GAMESS software, showed a strong correlation with experimental IC50 values (R²), validating the model's predictive capability.
Authors
- Falah Shareef Abed Suhail (ORCID: https://orcid.org/0000-0003-4944-2259)
Institutions
- Iraqi University (IQ)
Publication Details
- Journal
- Journal of Kufa for Chemical Sciences
- Published
- 2025-06-20
- DOI
- https://doi.org/10.36329/jkcm/2025/v4.i2.19415
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00