Study The Role Of Functional Proteins In Sera Oh Iraqi Patients With Alzheimers Disease

The aim of the present study is to expose novel mechanisms and concepts regarding amyloid beta , albumin and hemoglobin in sera of Iraqi Alzheimer`s disease (AD) patients , and also to examine the biochemical action of memantine on those parameters. . Sixty (60) diagnosed AD patients participated the present study and classified into four (4) groups: G3 (52-78) was composed of (15) newly diagnosed males / without treatment , G4 (64-90) years composed of (15) newly diagnosed females / without treatment , G5 (60-85) years composed of (15) males under treatment with memantine and G6 (65-73) years composed of (15) females also under treatment with memantine. Memantine used as 10 mg /one dose daily. Patients were compared with healthy subjects as two control groups: G1 composed of (15) males /(52-80) years and G2 composed of (15) females / (64-82) years.. Results of the present study have revealed that Aβ level was significantly increased in sera of G3 and G4 compared with G1 and G2 respectively, while it was significantly decreased in sera of G5 and G6 compared with G3 and G4 respectively, non significant difference was reported between (G5 and G1) and between (G4 and G3) , however the difference between G6 and G2 was significant. Albumin level was highly significant increased in G3 and G4 compared with G1 and G2 respectively while it was highly significant decreased in G5 and G6 compared with G3 and G4 respectively, the difference between (G5 and G1), (G6 and G2) and between (G3 and G4)was significant. Hemoglobin level was highly significant decreased in G3 and G4 compared with G1 and G2 respectively while it was significantly increased in G5 compared with G3 and highly significant in G6 compared with G4 , the difference between (G5 and G1) and between (G6 and G2) was non significant while it was highly significant between (G3 and G4). The present study submits unique and definite mechanisms regarding Aβ, hemoglobin and albumin (before and after treatment with memantine ) and exposes novel concepts to the clinical biochemistry in the term of the studied biochemical parameters. The present study also gives a hint to the difference between male and female AD patients regarding levels of the biochemical parameters before and after treatment.