Facile synthesis of Al<sub>2</sub>O<sub>3</sub> and Fe<sub>2</sub>O<sub>3</sub> via green chemistry for the potentiometric determination of Phenylephrine-HCl in pure form and pharmaceutical formulations

Phenylephrine (PHE) in its pure form and in pharmaceutical preparations can be determined using an easy-to-use, affordable, sensitive, and eco-friendly approach. The process is predicated on the synthesis of nano-iron oxide (Fe2O3) and nano-aluminum oxide (Al2O3) from the extract of the Melissa plant. The measurements were made between October 15, 2023, and January 15, 2024, at Tikrit University's College of Science, Department of Chemistry. This study's primary goal is to ascertain how much the electrical potential changes when copper wire is used instead of aluminum. There were four electrodes produced (I, II, III, IV). In a variety of PHE concentrations, the electrodes responded to the chemical appropriately (1x10-2_1x10-8) mol/L. Concerning the electrodes (II, IV), concerning the electrodes (II, IV), Regarding the electrodes (I, III), their response fell within the concentration range (1x10-2_1x10-6) mol/L. This range of concentrations showed a linear relationship. Table No. (1) displays the detection limit and quantitative limit values, both of which were good. The poles (I, II, III, IV) have Nernst inclinations of (54.0, 54.4, 57.571, 57.179) mv/decade, respectively. These values are in close proximity to the Nernst value for the single-charged ion, which is (59.15 mv/decade) over the number of degrees. For the electrodes that we made (I, II, III, IV), the pH (2_8) and the correlation coefficient (R) are, respectively, (0.9997, 0.9997, 0.9999, and 0.9998). The suggested approach was confirmed and contrasted with the approved approach. We were successful in this. The goal of the experiment is to produce nanomaterials from environmentally friendly sources. These methods have gained popularity due to their simplicity, affordability, and lack of environmental hazard. Additionally, when drugs are bound to nano-oxides, the outcomes are more favorable.