Plasminogen mutation–associated thrombotic microangiopathy and role of anticoagulation: a single institution case series
Patients with <i>PLG</i> mutation-associated TMAs appear to have a poor response to complement blockade therapy, suggesting that pathways in addition to or independent of complement dysregulation may be involved in some patients. Future studies are warranted to explore the role of anticoagulation in preventing recurrence in patients with <i>PLG</i> mutations.
Authors
- Senthil Sukumar (ORCID: https://orcid.org/0000-0002-0882-6793)
- Shreya Agarwal (ORCID: https://orcid.org/0000-0001-9790-496X)
- Spero R. Cataland (ORCID: https://orcid.org/0000-0001-8977-6910)
- Nicola Pozzi (ORCID: https://orcid.org/0000-0001-8561-798X)
- Camila Masias (ORCID: https://orcid.org/0000-0002-1380-3799)
- Anuja Java (ORCID: https://orcid.org/0000-0003-0433-238X)
Institutions
- Baptist Hospital of Miami (US)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- Washington University in St. Louis (US)
- Baptist Health South Florida (US)
- Saint Louis University (US)
- The Ohio State University (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.103012
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00