Mitral Annular Disjunction in Marfan Syndrome: A Multicenter Cardiovascular Magnetic Resonance Study
The high prevalence, large extent, and predominantly pan-annular distribution of MAD suggest a systemic annular pathology in MFS. Overall presence of MAD was not associated with changes to left heart parameters, aortic dimensions, and cardiovascular events. However, MAD, taking into account its extent and affected insertion sites, could serve as a potential marker of disease progression given the shown association of localizations and distance with LV dysfunction and remodeling as well as aortic enlargement and the formation of MVP.
Authors
- Vanessa Schmidt (ORCID: https://orcid.org/0000-0002-5851-1087)
- Carsten Gietzen (ORCID: https://orcid.org/0000-0002-2354-3847)
- Julian Alexander Luetkens (ORCID: https://orcid.org/0000-0002-7715-4636)
- Thorsten Gietzen (ORCID: https://orcid.org/0000-0001-7948-202X)
- Lenhard Pennig (ORCID: https://orcid.org/0000-0002-6606-9313)
- Moritz C. Halfmann (ORCID: https://orcid.org/0000-0001-7550-0171)
- Christopher Hohmann (ORCID: https://orcid.org/0000-0003-2821-4134)
- Reza Dehdab (ORCID: https://orcid.org/0000-0002-3496-8808)
- David Maintz (ORCID: https://orcid.org/0000-0002-8942-3776)
- Robert Terzis (ORCID: https://orcid.org/0009-0007-1068-8477)
- Philipp von Stein (ORCID: https://orcid.org/0000-0003-4548-3897)
- Lukáš Müller (ORCID: https://orcid.org/0000-0002-8626-4044)
- Lukas Goertz
- Patrick Krumm (ORCID: https://orcid.org/0000-0003-1705-8439)
- Jan M. Brendel (ORCID: https://orcid.org/0000-0002-2729-610X)
- Kilian Weiss (ORCID: https://orcid.org/0000-0003-4295-4585)
- Tilman Emrich (ORCID: https://orcid.org/0000-0002-6096-3154)
- Roman Johannes Gertz (ORCID: https://orcid.org/0000-0002-6414-4105)
- Leon Bischoff (ORCID: https://orcid.org/0000-0001-5193-5226)
- Jonathan Kottlors (ORCID: https://orcid.org/0000-0002-4966-0478)
- Kenan Kaya
- Jan Paul Janßen
Institutions
- University of Cologne (DE)
- Johannes Gutenberg University Mainz (DE)
- University Hospital Bonn (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University Children's Hospital Tübingen (DE)
- University Hospital Cologne (DE)
- Philips (Germany) (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Journal of Cardiovascular Magnetic Resonance
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jocmr.2025.101938
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00