Methodological framework and unified metrics for thrombus resolution analysis in the mouse inferior vena cava stenosis model
Integrating the IVC stenosis model enhanced by back-branch ligation with serial imaging and statistical modeling to derive unified thrombus resolution metrics-proportional resolution rate and time to half-maximum thrombus volume-provides a robust methodological framework. This framework may facilitate the design of preclinical trials using these metrics as standardized outcome measures.
Authors
- Ivan Budnik (ORCID: https://orcid.org/0000-0002-6652-2667)
- Anil Kumar Chauhan (ORCID: https://orcid.org/0000-0001-8554-0898)
- Mariia Kumskova (ORCID: https://orcid.org/0000-0002-2477-3011)
- Daniel R. Thedens (ORCID: https://orcid.org/0000-0002-4704-3185)
Institutions
- University of Iowa (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.103009
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- NHLBI Division of Intramural Research