Interplay Between Childhood Maltreatment, Subclinical Post‐Traumatic Stress Symptoms, and <scp>IQ</scp>: Findings From the <scp>EU</scp>‐<scp>GEI</scp> Multicentre Case–Control Study

ABSTRACT Introduction Evidence suggests that childhood maltreatment affects cognitive performance in both patients with psychosis and community controls. However, the interplay between childhood maltreatment, post‐traumatic stress symptoms (PTSS), and intelligence has not been investigated. This study investigated the relationship between childhood maltreatment, subclinical PTSS, and intelligence among patients with first‐episode psychosis (FEP) and community controls. Methods Patients with FEP ( N = 602) and controls ( N = 853) from the EU‐GEI study were assessed for childhood maltreatment, PTSS, and intelligence quotient (IQ). Results PTSS were associated with lower IQ among community controls but not among patients with FEP. In the FEP group, an interaction ( p = 0.044) between PTSS and childhood maltreatment on IQ was found, such that the association between PTSS and lower IQ was only present among those exposed to childhood maltreatment. No interaction was evident in controls ( p = 0.826). Conclusions The findings suggest the relevance of cognitive rehabilitation for FEP patients with childhood maltreatment and PTSS.

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Journal
Early Intervention in Psychiatry
Published
2025-08-01
DOI
https://doi.org/10.1111/eip.70079
Primary Topic
Child Abuse and Trauma
Type
article
Field-Weighted Citation Impact
0.00

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article

Interplay Between Childhood Maltreatment, Subclinical Post‐Traumatic Stress Symptoms, and IQ: Findings From the EU‐GEI Multicentre Case–Control Study

Celso Arango, Helen L. Fisher, Ilaria Tarricone, Lucia Sideli et al.
Early Intervention in Psychiatry
Child Abuse and Trauma
article

Interplay Between Childhood Maltreatment, Subclinical Post‐Traumatic Stress Symptoms, and IQ: Findings From the EU‐GEI Multicentre Case–Control Study

Celso Arango, Helen L. Fisher, Ilaria Tarricone, Lucia Sideli, Giovanna Marrazzo, Daniele La Barbera, Luis Alameda, Simona A. Stilo, Diego Quattrone, Jim van Os, Miquel Bernardo, Giada Tripoli, Robin M. Murray, Bart P. F. Rutten, Crocettarachele Sartorio, James B. Kirkbride, Fabio Seminerio, Baptiste Pignon, Craig Morgan, Giuseppe D’Andrea, Manuel Arrojo, Adriano Schimmenti, Cristina Marta Del‐Ben, Caterina La Cascia, Eva Velthorst, José Luis Santos, Charlotte Gayer‐Anderson, Julio Sanjuán, Victoria Rodríguez, Monica Aas, Andrea Tortelli, Giulia Trotta, Edoardo Spinazzola, Antonio Lasalvia, Paulo Rossi Menezes, Hannah E. Jongsma, Sarah Tosato, Laura Ferraro, Julio Bobes, Andrea Fontana, Pierre‐Michel Llorca, Marta Di Forti, Lieuwe de Haan, Peter B. Jones, Jean‐Paul Selten
article en

Abstract

ABSTRACT Introduction Evidence suggests that childhood maltreatment affects cognitive performance in both patients with psychosis and community controls. However, the interplay between childhood maltreatment, post‐traumatic stress symptoms (PTSS), and intelligence has not been investigated. This study investigated the relationship between childhood maltreatment, subclinical PTSS, and intelligence among patients with first‐episode psychosis (FEP) and community controls. Methods Patients with FEP ( N = 602) and controls ( N = 853) from the EU‐GEI study were assessed for childhood maltreatment, PTSS, and intelligence quotient (IQ). Results PTSS were associated with lower IQ among community controls but not among patients with FEP. In the FEP group, an interaction ( p = 0.044) between PTSS and childhood maltreatment on IQ was found, such that the association between PTSS and lower IQ was only present among those exposed to childhood maltreatment. No interaction was evident in controls ( p = 0.826). Conclusions The findings suggest the relevance of cognitive rehabilitation for FEP patients with childhood maltreatment and PTSS.

Early Intervention in PsychiatryVol. 19(8)
University of Verona (IT), Libera Università Maria SS. Assunta (IT), Universitat de València (ES), Universidade de São Paulo (BR), King's College London (GB), Université Clermont Auvergne (FR), University of Cambridge (GB), Università degli Studi di Enna Kore (IT), Maastricht University Medical Centre (NL), Instituto de Salud Carlos III (ES), Centre Hospitalier Universitaire Vaudois (CH), Hospital General Universitario Gregorio Marañón (ES), University Medical Center Utrecht (NL), Centre Hospitalier Universitaire Henri-Mondor (FR), Maastricht University (NL), Science Navigation Group (United Kingdom) (GB), GGZ Noord-Holland-Noord (NL), Centro de Investigación Biomédica en Red de Salud Mental (ES), Hospital Virgen de la Luz (ES), Complejo Hospitalario Universitario de Santiago (ES), Fondation FondaMental (FR), Istituto S.Anna Crotone (IT), Amsterdam Neuroscience (NL), GGZ Rivierduinen (NL), Instituto de Biomedicina de Sevilla (ES), Cambridgeshire and Peterborough NHS Foundation Trust (GB), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR), Institut National de Santé Publique (TN), Instituto de Investigación Sanitaria de Santiago (ES), Hospital Universitario Virgen del Rocío (ES), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Hôpital Maison Blanche (FR), Universitat de Barcelona (ES), University of Palermo (IT), University of Bologna (IT), University of Lausanne (CH)
Fundación Alicia Koplowitz, Universidad de Sevilla, Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades, Instituto de Investigación Sanitaria de Santiago de Compostela, Universidad Internacional de La Rioja, Fondation FondaMental, Amsterdam University Medical Centers, Leverhulme Trust, King's College London, European Commission, Institut National de la Santé et de la Recherche Médicale, Fundação de Amparo à Pesquisa do Estado de São Paulo, Universiteit van Amsterdam, Universiteit Utrecht, Universiteit Maastricht, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Rivierduinen, Universitat de València, Università degli Studi di Palermo, Universidade de São Paulo, Universitat de Barcelona, Università di Bologna, Universidad de Oviedo, Centre Hospitalier Universitaire Vaudois, Centro de Investigación Biomédica en Red de Salud Mental, Università degli Studi di Verona, INCLIVA Instituto de Investigación Sanitaria, Horizon 2020 Framework Programme, HORIZON EUROPE Framework Programme, Medical Research Council, Economic and Social Research Council, Instituto de Salud Carlos III, European Regional Development Fund, National Institute of Mental Health
Openalex Percentile: Top 72%
Child Abuse and Trauma
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