Longitudinal investigation of sleep and circadian rest-activity rhythms in non-small cell lung cancer patients during immunotherapy and associations with fatigue, depression, and perceived stress
Sleep disturbances, circadian disruption, and psychological symptom burden in NSCLC patients were greatest prior to and shortly after initiation of ICI treatment, with gradual improvement over the first five months. However, inter-individual differences in sleep and circadian disturbances were evident and linked to psychological symptoms.
Authors
- Lisa M. Wu (ORCID: https://orcid.org/0000-0003-2241-9905)
- Ali Amidi (ORCID: https://orcid.org/0000-0003-2921-9797)
- Peter Meldgaard (ORCID: https://orcid.org/0000-0002-5788-4463)
- L Strom
- Sonia Ancoli‐Israel (ORCID: https://orcid.org/0000-0002-0662-8865)
- Robert Zachariae (ORCID: https://orcid.org/0000-0001-9076-3068)
- Mats Lekander
- Daniel K. Mroczek (ORCID: https://orcid.org/0000-0003-3748-5059)
Institutions
- Northwestern University (US)
- University of San Diego (US)
- Stockholm University (SE)
- Aarhus University (DK)
- UC San Diego Health System (US)
- Aarhus University Hospital (DK)
- Karolinska Institutet (SE)
- University of California San Diego (US)
Publication Details
- Journal
- Sleep Medicine
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1016/j.sleep.2025.106740
- Citations
- 3
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.73