NLRP3 inflammasome impairs fracture repair in Rheumatoid arthritis through RhoA/Rac1-IL1β axis-mediated suppression of osteoblast differentiation
This study provides novel insights into the mechanisms underlying delayed fracture healing in RA and highlights the potential therapeutic benefits of targeting the NLRP3 inflammasome.
Authors
- Yifan Dai (ORCID: https://orcid.org/0000-0003-2872-8442)
- Wen Sun (ORCID: https://orcid.org/0000-0002-8111-8865)
- Fen Miao
- R. Jin
- Ziwei Yan (ORCID: https://orcid.org/0000-0003-2943-2707)
- Lu Li (ORCID: https://orcid.org/0000-0002-7302-8528)
- Hua Wang (ORCID: https://orcid.org/0000-0002-2605-5697)
- Yan Xu (ORCID: https://orcid.org/0000-0002-2636-7594)
- Yue Chen (ORCID: https://orcid.org/0000-0002-9529-1626)
- H. Cai
Institutions
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1016/j.jot.2025.07.012
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61