Real-world evidence of chemotherapy effects in advanced pancreatic ductal adenocarcinoma: prognostic significance of TP53 status in gemcitabine plus nab-paclitaxel therapy
In Japanese real-world data, GnP showed superior TTP compared with FFX for advanced PDAC. <i>TP53</i> status may serve as a prognostic biomarker in patients receiving GnP therapy.
Authors
- Kazuya Sugimori (ORCID: https://orcid.org/0000-0003-1596-0744)
- Yoshimasa Suzuki (ORCID: https://orcid.org/0009-0001-7948-5332)
- Hajime Yamazaki (ORCID: https://orcid.org/0000-0002-9034-4370)
- Masataka Kudo (ORCID: https://orcid.org/0000-0001-5916-1202)
- Shin Maeda (ORCID: https://orcid.org/0000-0002-0246-1594)
- Keigo Kawashima (ORCID: https://orcid.org/0000-0003-0985-1111)
- Hiroto Miwa (ORCID: https://orcid.org/0000-0001-9844-642X)
- M. Sugimori
- Masanori Oshi (ORCID: https://orcid.org/0000-0002-1404-1570)
- Yu Kanemaru (ORCID: https://orcid.org/0000-0001-5810-5524)
- S. Onodera
- Chikara Kunisaki (ORCID: https://orcid.org/0000-0002-0843-8766)
- Hiromi Tsuchiya
- Akito Nozaki (ORCID: https://orcid.org/0000-0002-3310-6632)
- Akane Hirotani (ORCID: https://orcid.org/0000-0002-9188-5187)
- Manabu Morimoto (ORCID: https://orcid.org/0000-0002-3940-9634)
Institutions
- Yokohama City University Medical Center (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- ESMO Gastrointestinal Oncology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1016/j.esmogo.2025.100221
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science