Synthesis and In Vitro Metabolic Profiling of the Selective Androgen Receptor Modulator (SARM) LY305
The transdermal SARM LY305 was successfully synthesized and subjected to in vitro metabolic studies, yielding chromatographic and mass spectral data that support improving comprehensive anti-doping tests. To the best of our knowledge, no published experimental data exist that report on the in vitro metabolic profile of LY305, a substance that might undergo further (pre)clinical evaluation.
Authors
- Francesco Paolo Busardò (ORCID: https://orcid.org/0000-0002-3082-4532)
- Giorgi Kobidze (ORCID: https://orcid.org/0009-0001-9920-2336)
- Mario Thevis (ORCID: https://orcid.org/0000-0001-5972-8854)
- Hui‐Chung Wen
- Tristan Möller
Institutions
- TH Köln - University of Applied Sciences (DE)
- Marche Polytechnic University (IT)
- German Sport University Cologne (DE)
- University of Cologne (DE)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1002/rcm.10124
- Citations
- 2
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Deutsche Sporthochschule Köln
- Bundesministerium des Innern, für Bau und Heimat
- Manfred Donike Institut für Dopinganalytik