NADPH Oxidase 4 Deficiency Enhances Dendritic Cell-mediated IL-12 Production and Th1 Responses in Mycobacterium tuberculosis Infection
NOX4 negatively regulates IL-12 production in Mtb-infected DCs, suppressing Th1-mediated immunity. Its absence enhances Th1 responses, improves immune control of Mtb. Targeting NOX4 may improve tuberculosis outcomes by strengthening host immunity.
Authors
- Ji-Hwan Ryu (ORCID: https://orcid.org/0000-0001-6969-7465)
- Sang‐Won Choi (ORCID: https://orcid.org/0000-0002-1603-0576)
- Yura Ha (ORCID: https://orcid.org/0000-0002-3118-8312)
- Hongmin Kim (ORCID: https://orcid.org/0000-0002-9215-2831)
- Lee-Han Kim
- Ju Mi Lee (ORCID: https://orcid.org/0000-0002-3396-7838)
- Kyung-min Kim (ORCID: https://orcid.org/0000-0002-8135-821X)
- Seung‐Hyun Lee (ORCID: https://orcid.org/0000-0001-7549-9430)
- Sung Jae Shin (ORCID: https://orcid.org/0000-0003-1849-4435)
- Hong‐Hee Choi (ORCID: https://orcid.org/0009-0000-1794-302X)
Institutions
- Yonsei University (KR)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1016/j.jmii.2025.08.004
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Korea National Institute of Health